Affect with drug, producing odd reaction laced with sulphur (9)

I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

An envelope (‘laced with’) of S (chemical symbol, ‘sulphur’ aka sulfur) in NARCOTIE, an anagram (‘odd’) of ‘reaction’. Yes, it is a straight anagram, but this parsing makes sense of ‘laced with’.