What does the cryptic crossword clue "Appease pair, needing sedative, going without it? (10)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Appease pair, needing sedative, going without it? (10)

Times Cryptic #28050 | 9 Across | 2021-08-07

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