What does the cryptic crossword clue "Challenges again from different setters (7)" mean?

The definition is "Challenges again". The wordplay uses an anagram. anagram of SETTERS ("setters") [anagram: "from"] = RETESTS; definition: "Challenges again" The answer is RETESTS.

Challenges again from different setters (7)

Guardian Cryptic #28952 | 17 Across | 2022-12-28 flower

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