What does the cryptic crossword clue "Depict pain that's mistreated and is reason for operation (12)" mean?

The definition is "reason for operation". The wordplay uses anagram, charade. anagram of DEPICTPAIN ("Depict pain") + IS (synonym of "is") [anagram: "mistreated"] = APPENDICITIS; definition: "reason for operation" The answer is APPENDICITIS.

Depict pain that's mistreated and is reason for operation (12)

Times Cryptic #28667 | 18 Across | 2023-07-28 flower

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