What does the cryptic crossword clue "Expedition set off (4)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Expedition set off (4)

Daily Mail Cryptic #16673 | 25 Down | 2021-09-28

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Also seen in

Telegraph Prize Cryptic #3146 (2022-02-06) Guardian Cryptic #27371 (2017-12-04)