What does the cryptic crossword clue "Female twit in fiction (6)" mean?

The definition is "Female". The wordplay uses a charade (building blocks). ASS (synonym of "twit") + LIE (synonym of "fiction"); definition: "Female" The answer is Lassie.

Female twit in fiction (6)

Telegraph Prize Cryptic #3133 | 27 Across | 2021-11-07 flower

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