What does the cryptic crossword clue "Fibrous substance produced by English: first out? The opposite (7)" mean?

The definition is "Fibrous substance". The wordplay uses a charade (building blocks). E (synonym="English") + LAST (synonym="LAST") + IN (synonym="first out – the opposite") = ELASTIN; definition: "Fibrous substance" The answer is ELASTIN.

Fibrous substance produced by English: first out? The opposite (7)

Times Cryptic #28724 | 5 Down | 2023-10-03 flower

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