What does the cryptic crossword clue "For instance, an anagram that's shrewd in the extreme (8)" mean?

The definition is "shrewd in the extreme". The wordplay uses an anagram. anagram of INSTANCE ("instance,") [anagram: "anagram"] = CANNIEST; definition: "shrewd in the extreme" The answer is CANNIEST.

For instance, an anagram that's shrewd in the extreme (8)

Times Cryptic #28597 | 27 Across | 2023-05-08 flower

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