What does the cryptic crossword clue "Game up in Italian river, endlessly deep (4)" mean?

The definition is "Game up". The wordplay uses a charade (building blocks). PO (synonym="PO") + LO (synonym="LO") = POLO; definition: "Game up" The answer is POLO.

Game up in Italian river, endlessly deep (4)

Times Cryptic #28671 | 10 Across | 2023-08-02 flower

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