What does the cryptic crossword clue "Great leader bitter, cross with Queen (9)" mean?

The definition is "Queen". The wordplay uses a charade (building blocks). ALE (synonym of "bitter,") + X (synonym of "cross") + AND (synonym of "with") + ER (synonym of "Queen"); definition: "Great leader" The answer is Alexander.

Great leader bitter, cross with Queen (9)

Telegraph Prize Cryptic #3060 | 16 Down | 2020-06-14 flower

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