What does the cryptic crossword clue "Greatly affect writer in university department (5)" mean?

The definition is "Greatly". The wordplay uses a charade (building blocks). U (synonym of "university") + PEN (synonym of "writer") + D (abbreviation of "department"); definition: "Greatly affect" The answer is UPEND.

Greatly affect writer in university department (5)

Independent Cryptic #11670 | 10 Across | 2024-03-06 flower

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