What does the cryptic crossword clue "Huge region over in USA is Appalachia (4)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Huge region over in USA is Appalachia (4)

Independent Cryptic #12202 | 9 Across | 2025-11-17 flower

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Times Cryptic #26764 (2017-06-29)