What does the cryptic crossword clue "Infectious game advanced with six in the lead (8)" mean?

The definition is "Infectious". The wordplay uses a charade (building blocks). VI (synonym="six") + RU (synonym="game") + LENT (synonym="advanced") = VIRULENT The answer is VIRULENT.

Infectious game advanced with six in the lead (8)

Independent Cryptic #11640 | 16 Down | 2024-01-31 flower

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