What does the cryptic crossword clue "It could kill you to let go when on limb! (7)" mean?

The wordplay uses a charade (building blocks). FIRE (synonym="‘let go’ – dismiss from employment") + ARM (synonym="‘limb’") = FIREARM The answer is FIREARM.

It could kill you to let go when on limb! (7)

Guardian Cryptic #29357 | 5 Across | 2024-04-15 flower

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