It may make basket cases of reclusive isolates, over from the east (5)

Times Cryptic #28658 | 13 Across | 2023-07-18
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I haven't cracked this one yet — but the brilliant team at Times for the Times have:

R{eclusiv}E + I{solate}S [cases of…], + O (over) all reversed [from the east]. Young shoots of the willow tree.

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