Lead boxes contaminate oxygen, substance used in clinical trials (7)

Guardian Cryptic #28996 | 5 Across | 2023-02-17
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I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

A charade of PLACEB, an envelope (‘boxes’) of LACE (‘contaminate’) in PB (chemical symbol, ‘lead’); plus O (chemical symbol, ‘oxygen’).

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