Leader to lead with a venerable lady in the family (3,6)

Guardian Cryptic #29552 | 15 Across | 2024-11-28
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I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

TO + PB(symbol for the chemical element, lead) plus ( with ) A + NANA(an informal term for one’s grandmother, a venerable lady in the family).

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