What does the cryptic crossword clue "Lord who ran to embrace murderer — and 22A's addiction? (7)" mean?

The wordplay uses a container (one word inside another). CAIN (synonym="character in the Book of Genesis who murdered his brother Abel; murderer") in COE (synonym="reference Lord Sebastian COE [born 1956], former Olympic and world record athlete; Lord who ran") = COCAINE The answer is COCAINE.

Lord who ran to embrace murderer — and 22A's addiction? (7)

Independent Cryptic #11921 | 15 Across | 2024-12-24 flower

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