What does the cryptic crossword clue "Male variant of chromosome or female? (4)" mean?

The definition is "Male". The wordplay uses a charade (building blocks). LAD (synonym="=male") + Y (synonym="=variant of chromosome") = LADY; definition: "female?" The answer is LADY.

Male variant of chromosome or female? (4)

Independent Cryptic #11922 | 3 Down | 2024-12-25 flower

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