What does the cryptic crossword clue "Mark’s intense struggle with scientist playing God (12)" mean?

The definition is "scientist playing God". The wordplay uses a charade (building blocks). anagram of FRANK (synonym="mark, e.g. a letter") + INTENSE (synonym="INTENSE") = FRANKENSTEIN; definition: "scientist playing God" The answer is FRANKENSTEIN.

Mark’s intense struggle with scientist playing God (12)

Guardian Cryptic #29419 | 27 Across | 2024-06-26 flower

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