What does the cryptic crossword clue "Most of all, smokers suffering from nonprofit venture (9)" mean?

The wordplay uses an anagram. anagram of AL (synonym="AL") + SMOKERS (synonym="SMOKERS") = LOSSMAKER The answer is LOSSMAKER.

Most of all, smokers suffering from nonprofit venture (9)

Guardian Cryptic #29333 | 15 Down | 2024-03-18 flower