On reflection ultimately calamitous, U.K. to consume excessively American puzzles (7)

Guardian Cryptic #29669 | 1 Down | 2025-04-15
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I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

A reversal (on reflection) of [calamitou]S U K + OD (overdose – consume excessively) + US

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