What does the cryptic crossword clue "Opposed to a way to secure profit (7)" mean?

The definition is "Opposed to". The wordplay uses a charade (building blocks). AGAIN (synonym="profit") + S (first_letter="secure") + T (first_letter="to") = AGAINST; definition: "Opposed to" The answer is AGAINST.

Opposed to a way to secure profit (7)

Daily Mail Cryptic #16945 | 2 Down | 2022-10-13 flower

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