Painkiller, heroin, injected in butt or leg (9)

Guardian Cryptic #29809 | 19 Across | 2025-09-25
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I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

definition: endorphins are pain relieving chemicals produced by the brain H (heroin) inside: END=”butt” + OR (from surface) + PIN=”leg”

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