What does the cryptic crossword clue "Reconciled where gender is not fixed? (8)" mean?

The definition is "Reconciled". The wordplay uses an anagram. anagram of GENDER + IS = RESIGNED; definition: "Reconciled" The answer is RESIGNED.

Reconciled where gender is not fixed? (8)

Independent Cryptic #1660 | 19 Down | 2021-12-19 flower