What does the cryptic crossword clue "Separation of state and religion curses Mali after Reformation (10)" mean?

The definition is "Separation of state and religion". The wordplay uses an anagram. anagram of CURSES (synonym="CURSES") + MALI (synonym="MALI") = SECULARISM The answer is SECULARISM.

Separation of state and religion curses Mali after Reformation (10)

Guardian Cryptic #28981 | 11 Across | 2023-01-31 flower

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