What does the cryptic crossword clue "Set off at ten with doe in need of treatment (8)" mean?

The definition is "Set". The wordplay uses an anagram. anagram of AT + TEN + DOE = DETONATE; definition: "Set off" The answer is DETONATE.

Set off at ten with doe in need of treatment (8)

Independent Cryptic #1775 | 16 Down | 2024-03-03 flower