What does the cryptic crossword clue "Setter’s work leads to iritis, awful eye problem (6)" mean?

The definition is "eye problem". The wordplay uses a charade (building blocks). MY (abbreviation="Setter's") + OP (abbreviation="work") + I (first_letter="iritis,") + A (first_letter="awful") = MYOPIA; definition: "eye problem" The answer is MYOPIA.

Setter’s work leads to iritis, awful eye problem (6)

Daily Mail Cryptic #16521 | 26 Across | 2021-02-26 flower

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