What does the cryptic crossword clue "Son lost it: any reason? (6)" mean?

The definition is "reason". The wordplay uses anagram, charade. anagram of ITANY ("it: any") [anagram: "lost"] + S (abbreviation of "Son") = SANITY; definition: "reason?" The answer is SANITY.

Son lost it: any reason? (6)

Guardian Cryptic #29158 | 7 Down | 2023-08-25 flower

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