What does the cryptic crossword clue "Speak of regret and the effect, first of all (5)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Speak of regret and the effect, first of all (5)

Telegraph Prize Cryptic #3279 | 24 Down | 2024-08-25 flower

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