What does the cryptic crossword clue "This is one party game (6)" mean?

The definition is "game". The wordplay uses a charade (building blocks). CLUE (synonym of "This is one") + DO (synonym of "party"); definition: "game" The answer is CLUEDO.

This is one party game (6)

Guardian Cryptic #29228 | 25 Across | 2023-11-15 flower

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