What does the cryptic crossword clue "Those who mesmerize pythons sit uneasily (10)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Those who mesmerize pythons sit uneasily (10)

Times Sunday #5006 | 13 Down | 2022-05-08 flower

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