What does the cryptic crossword clue "Tone of medic gripped by fatigue (6)" mean?

The definition is "Tone". The wordplay uses charade, container. MB (synonym of "medic") + TIRE (synonym of "fatigue") [container: "gripped"]; definition: "Tone" The answer is TIMBRE.

Tone of medic gripped by fatigue (6)

Times Cryptic #29176 | 6 Across | 2025-03-13 flower

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