What does the cryptic crossword clue "Treating the rash wrongly is fateful (5,10)" mean?

The definition is "fateful". The wordplay uses an anagram. anagram of TREATING + THE + RASH = EARTHSHATTERING; definition: "fateful" The answer is EARTHSHATTERING.

Treating the rash wrongly is fateful (5,10)

Guardian Cryptic #24203 | 16 Across | 2007-10-09 flower

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