What may be read as 221? (5,3,2,1,4)

Guardian Cryptic #29264 | 22 Across | 2023-12-28
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I haven't cracked this one yet — but the brilliant team at Fifteensquared have:

A different kind of ‘lift and separate’: the clue refers to the answers to 2dn (three men) and 21ac (AT SEA) – the title of Jerome K. Jerome’s hilarious book

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