What does the cryptic crossword clue "What's fatal for many — not opening best medicine? (8)" mean?

The definition is "best medicine?". The wordplay uses a deletion. LAUGHTER (deletion) = LAUGHTER; definition: "best medicine?" The answer is LAUGHTER.

What's fatal for many — not opening best medicine? (8)

Guardian Cryptic #28217 | 7 Down | 2020-08-20 flower

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