What does the cryptic crossword clue "Wine's ruined piece of tough tissue (5)" mean?

The definition is "tissue". The wordplay uses an anagram. anagram of WINE'S = SINEW; definition: "tissue" The answer is SINEW.

Wine's ruined piece of tough tissue (5)

Daily Mail Cryptic #17135 | 17 Across | 2023-07-06 flower