What does the cryptic crossword clue "Wise guys, most are genuinely ignorant, first of all (4)" mean?

This cryptic clue uses wordplay to arrive at the answer. Visit the page for progressive hints — definition, wordplay type, and a full step-by-step explanation.

Wise guys, most are genuinely ignorant, first of all (4)

Telegraph Prize Cryptic #3201 | 24 Down | 2023-02-26 flower

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