Across
12a
Artificial grit, target of 6 22? (7,6)
Lead boxes contaminate oxygen, substance used in clinical trials (7)
I haven't cracked this one yet — but Fifteensquared have:
A charade of PLACEB, an envelope (‘boxes’) of LACE (‘contaminate’) in PB (chemical symbol, ‘lead’); plus O (chemical symbol, ‘oxygen’).
3 last seen in coat pocket (4)
I haven't cracked this one yet — but Fifteensquared have:
A charade of T (‘last seen in coa T ‘) plus WEE (small, ‘pocket’).
Very hot — or very nippy? (10)
I haven't cracked this one yet — but Fifteensquared have:
Double cefinition – the second referring to speed.
See 1
See 16
Unaware where the bulbs have gone? (2,3,4)
I haven't cracked this one yet — but Fifteensquared have:
Definition and literal interpretation.
13a
Che Guevara perhaps in US city, revolutionary air around me in target of 6 22? (5-8)
See 27
Button done on the outside, silk finally threaded through eyelet casually (6,3)
Country held hostage by learned cheat (8)
See 25
Aquatic insect in river starts to nudge drifting reeds around fish (4,6)
17a
Loco senior dancing around short nude (4,5)
Daddy's skin covered with pig and head of tiger — tattoos, say? (4,3)
I haven't cracked this one yet — but Fifteensquared have:
An envelope (‘covered with’) of DY (‘ D add Y ‘s skin’) in BOAR (‘pig’) plus T (‘head of T iger’).
See 3
Down
Contemptible dope (3-4)
29a
Target of 6 22, M&M and Eminem by the sound of it? (5,7)
I want to squeeze brother, no other — keep it in the family? (7)
I haven't cracked this one yet — but Fifteensquared have:
An envelope (‘to squeeze’) of BR (‘ BR other no other’) in I NEED (‘I want’).
22d
Spooner's taster of kind of bread stick grabbing butt, perhaps? (6-6)
Designed article stuffed with silver tissue (9)
Girl entering country detailed language (7)
More than one difference emerges and it's not right (13)
Union member on railway conservation (9)
Sherry sadly unopened (7)
European politician, sovereign or ruler (7)
I haven't cracked this one yet — but Fifteensquared have:
A charade of E (‘European’) plus MP (‘politician’) plus ER (Elizabeth Regina or Eduardus Rex, onetime ‘soverieign’) plus ‘or’.
Abomination observed by me, reportedly (7)
See 6
24a
Sharp mint, target of 6 22? (5,6)
Type letters or click words in the clue