Across
Weed out taking back LSD E and speed (9)
I haven't cracked this one yet — but Fifteensquared have:
The word order is somewhat misleading here: it’s E (for the surface, we can read this as a slang abbreviation for the drug ecstasy) + RATE (speed), containing ACID (slang for LSD = abbreviation for the hallucinogenic drug lysergic acid diethylamide) reversed (back).
Vessel carrying vital liquid in 23 or (5)
I haven't cracked this one yet — but Fifteensquared have:
Hidden answer (in . . .) in [arcadi] A OR TA [getes], which is what we get after resolving the references to 23d and 6d. A blood vessel.
Dog Henry discovered with no lead (5)
Investigator concerned with sound of spook (9)
I haven't cracked this one yet — but Fifteensquared have:
IN (concerned with, as in “a career in finance”) + homophone (sound) of SPECTRE (ghost = spook).
Approaching eccentric grannie (7)
Let me in Rough Crossing - a small space for lead perhaps? (7)
Right sort of ale? (4)
W Professional Foul r (5)
I haven't cracked this one yet — but Fifteensquared have:
Anagram (foul) of HACK + last letter (term) of [professiona] L .
Man possibly taken for a ride in the interior (4)
I haven't cracked this one yet — but Fifteensquared have:
Inner letters (in the interior) of [m] ISLE [d] (taken for a ride = slang for deliberately deceived). Definition by example: the Isle of Man.
Wariness after colt's moved nearer centre in public sale (7)
I haven't cracked this one yet — but Fifteensquared have:
CAUTION (wariness), with the C (abbreviation for colt, in horse-racing statistics) moved a couple of places towards the centre of the word.
Ill-prepared like a lazy Eng Lit candidate? Yes (7)
Writing material I expanded for radio - essentially unkind somehow (9)
Frantic fear and trepidation initially concerning (5)
I haven't cracked this one yet — but Fifteensquared have:
Anagram (frantic) of FEAR + initial letter of T [repidation]. A slightly obscure definition but one recognised by the dictionaries: as in “to enquire after someone’s health”.
I will leave prodigy for a related group (5)
After a tripe spread I have a laxative (9)
I haven't cracked this one yet — but Fifteensquared have:
I’VE (contraction of “I have”) after an anagram (spread) of A TRIPE . Not to be confused with an aperitif, which comes from the same Latin / French root word but means something very different.
Down
She has a flashy mate a male in prison (6)
I haven't cracked this one yet — but Fifteensquared have:
A + HE (male), in PEN (prison). Female (mate) of a peacock; it’s the male that has the big flashy tail.
A gap where canula bends (6)
Town east of Glasgow centre of coiffure equipment? (7)
I haven't cracked this one yet — but Fifteensquared have:
Inner letters (centre) of [h] AIRDRIE [r] (also spelled hairdryer: coffure equipment).
Variable in flight (6)
Home fit for a hermit? Squire’s gutted as hell (8)
I haven't cracked this one yet — but Fifteensquared have:
S [quir] E (gutted = inner letters removed) + AS HELL . The “hermit” is a hermit crab, which doesn’t have a hard outer shell and makes its home in the discarded shell of some other sea creature.
Flowers to discern inscribed in chair back (7)
I haven't cracked this one yet — but Fifteensquared have:
GET (to discern = understand, as in “you still don’t get it”), in SEAT (chair) reversed (back). Flowering plants otherwise known as marigolds.
She makes a good speech acting in gold braid (8)
Artist from China with inner determination (8)
Partial farewell for a sheep (3)
Interpretations and sources in Rosencrantz And Guildenstern Are Dead in filleted Shakespeare works (8)
I haven't cracked this one yet — but Fifteensquared have:
Anagram (. . . works) of a lot of separate bits: first letters (sources) of R [osencrantz] + G [uildenstern], A (abbreviation for are = unit of area = 100 square metres), D (abbreviation for dead), IN , and S [hakespear] E (filleted = inner letters removed).
Adult seen on closed-circuit: “I damage car maybe - it’s not on purpose” (8)
Obstruct current in two taps (apparently) (8)
I haven't cracked this one yet — but Fifteensquared have:
I (scientific symbol for electrical current) in H AND C (two taps: abbreviations for hot and cold water taps) + AP (ap. = abbreviation for apparent or apparently, according to Chambers). Handicap, as a verb = to hinder or obstruct.
Empty-headed happy youth (3)
I haven't cracked this one yet — but Fifteensquared have:
[g] LAD (happy) without the first letter (head).
Artist’s photo like that will do (7)
Song about rascal in idyllic setting (7)
Maintenance of small instrument restraining piano on record (6)
I haven't cracked this one yet — but Fifteensquared have:
UKE (short for ukulele, like a guitar but smaller = small instrument) containing P (p, in musical notation = abbreviation for Italian piano = quietly), then EP (abbreviation for extended-play record).
A major star’s alternative broadcast (6)
City edition is maybe out this way? (6)
Type letters or click words in the clue