Across
Huge region over in USA is Appalachia (4)
Spar put in advertisement for email manager (10)
Sober sailors ring us after rough time (10)
Appropriate to include new and shocking report (4)
Writer takes unpleasantly serious direction (6)
Cross, having endless pain in face (8)
Greeks initially beat back a bloodsucker (4)
Change in mood perhaps in 50 consumed by disease (10)
Charming Charlie in with tradesmen (10)
Ultimate in consular assistance for Sally (4)
Artist in comeback managed act with lion (8)
Means business (6)
Pretty Woman's noisy scene finally cut (4)
Charge at goal line recklessly (10)
Opposition wants taxes introduced to an island (10)
Down
Solid coach up street and against centre of driveway (11)
Lark circling seaman on cape in coldest area (9)
Round mass in pipe unsettled one? Smoker here blew top! (7)
Sod's Law? Doc for me, suffering terrible hangover! (5,2,8)
Mum succeeded with second period in therapy (7)
Two tons on farm transport (5)
Organ for example taken in by Royal Academy student (5)
Male in CIA put up notice that guarantees good time (6,5)
Distressed hill folk spread out newly-mown grass (9)
A sinner at last was in church for cleansing service! (3,4)
Great moves by wingers from Ards in blinder (4,3)
What was tender of Italians entertaining British stars? (5)
Passing remarks about Republican circle (5)
Type letters or click words in the clue